منابع مشابه
Structural insights into eukaryotic DNA replication
THREE DNA POLYMERASES OF THE B FAMILY FUNCTION AT THE REPLICATION FORK IN EUKARYOTIC CELLS: DNA polymerases α, δ, and ε. DNA polymerase α, an heterotetramer composed of two primase subunits and two polymerase subunits, initiates replication. DNA polymerases δ and ε elongate the primers generated by pol α. The DNA polymerase from bacteriophage RB69 has served as a model for eukaryotic B family p...
متن کاملInsights into DNA replication from the third domain of life.
T discovery of the Archaea (1), the third domain of life, has reinvigorated efforts to understand the phylogenetic relationships among all forms of life. It is therefore not surprising that the recent completion of four archaeal genomes (2–5) created a f lurry of excitement among biologists (Genetics, Vol. 152). A comparison of genome sequences reveals that the prokaryotes, Archaea and Bacteria...
متن کاملCrystal structure of the GINS complex and functional insights into its role in DNA replication.
The GINS complex, which contains the four subunits Sld5, Psf1, Psf2, and Psf3, is essential for both the initiation and progression of DNA replication in eukaryotes. GINS associates with the MCM2-7 complex and Cdc45 to activate the eukaryotic minichromosome maintenance helicase. It also appears to interact with and stimulate the polymerase activities of DNA polymerase epsilon and the DNA polyme...
متن کاملMolecular insights into error-prone DNA replication and error-free lesion bypass.
6·4 pp CPD error propensity when dealing with undamaged DNA, which distinguishes them from known high-fidelity DNA polymerases. Most of their biological roles and functions have not been elucidated yet. Nevertheless, recent investigations suggest the involvement of pol L together with poll;, in error-prone translesion DNA synthesisPJ Furthermore, it has been shown that pol L possesses lyase act...
متن کاملStructural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control.
Activation of the DNA replication checkpoint by the ATR kinase requires protein interactions mediated by the ATR-activating protein, TopBP1. Accumulation of TopBP1 at stalled replication forks requires the interaction of TopBP1 BRCT5 with the phosphorylated SDT repeats of the adaptor protein MDC1. Here, we present the X-ray crystal structures of the tandem BRCT4/5 domains of TopBP1 free and in ...
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ژورنال
عنوان ژورنال: Structure
سال: 2004
ISSN: 0969-2126
DOI: 10.1016/j.str.2004.09.007